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REVIEW ARTICLE
Year : 2021  |  Volume : 7  |  Issue : 2  |  Page : 49-54

Interleukin-17: Is it a predictable biomarker for periodontal disease?


1 Associate Professor, Department of Dentistry, Sree Gokulam Medical College and Research Foundation, Venjaramoodu, Thiruvananthapuram, Kerala, India
2 Consultant Periodontist and Implantologist, Department of Dentistry, Sree Gokulam Medical College and Research Foundation, Venjaramoodu, Thiruvananthapuram, Kerala, India

Correspondence Address:
Chandran Preeja
Associate Professor, Department of Dentistry, Sree Gokulam Medical College and Research Foundation, Venjaramoodu, Thiruvananthapuram, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijohr.ijohr_30_20

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Periodontal disease is a multifactorial disease affecting the supporting tissues of the teeth and many etiologic factors are implicated in etiopathogenesis of periodontal disease. Although pathogenic bacteria have been the main causative factor in periodontal disease, host response accounts for the majority of periodontal destruction by releasing various inflammatory mediators, which has a negative impact on the periodontium. The host immune responses are regulated by various classes of T-cell subsets. Initially, periodontal disease can be explained with the T-helper 1/T-helper 2 paradigm. However, the discrepancies associated with it have led to the discovery of T-helper 17, which is responsible for the secretion of the cytokine interleukin-17 (IL-17). IL-17 is mainly a proinflammatory cytokine associated with periodontal inflammation, but controversies still exist with regard to whether they have a protective or destructive role in periodontal disease. Thus, the emergence of IL-17 has opened a new perspective of periodontal disease pathogenesis, but more number of researches is needed in this field to consider IL-17 as a predictable biomarker for periodontal disease.


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