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Year : 2016  |  Volume : 2  |  Issue : 1  |  Page : 5-11

Resorptive Cells in Health and Disease

1 Department of Oral Pathology and Microbiology, Bhojia Dental College, Baddi, Solan, Himachal Pradesh, India
2 Department of Prosthodontics, Bhojia Dental College, Baddi, Solan, Himachal Pradesh, India

Correspondence Address:
Swati Gautam
Department of Oral Pathology and Microbiology, Bhojia Dental College, Baddi, Solan, Himachal Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2393-8692.184727

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Clastic cells are responsible for the resorption of mineralized matrix of hard tissues. Bone resorbing cells are called osteoclasts; however, they are able to resorb mineralized dental tissues or calcified cartilage, and then, they are called odontoclasts and chondroclasts, respectively. Clastic cells form when mononuclear precursors derived from a monocyte-macrophage cell lineage are attracted to certain mineralized surfaces and subsequently fuse and adhere to them for exerting their resorbing activity. The clastic cells are responsible for degradation of calcified extracellular matrix composed of organic molecules and hydroxyapatite. This process is mainly required in bone turnover and growth, spontaneous and induced (orthodontic) tooth movement, tooth eruption, and bone fracture healing, as well as in pathological conditions, such as osteoporosis, osteoarthritis, and bone metastasis. In addition, they are responsible for daily control of calcium homeostasis. Clastic cells also resorb the primary teeth for shedding before the permanent teeth erupt into the oral cavity.

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