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ORIGINAL ARTICLE
Year : 2016  |  Volume : 2  |  Issue : 2  |  Page : 96-99

Oral epithelial cells in pemphigus vulgaris: An electronmicroscopic study in Indian population


1 Department of Oral Pathology and Microbiology, Nanded Rural Dental College and Research Center, Nanded, India
2 Department of Oral Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India

Correspondence Address:
Eesha Thakare
Shiv Multi Speciality Dental Clinic, First Floor, Akshay Plaza, Jatharpeth, Akola - 444 005, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2393-8692.196122

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Aim: Pemphigus, life-threatening illness affects only 1-5 patients per million populations per year. Cell junctions (desmosomes) are best visualized using either conventional or freeze-fracture electron microscopy. This is the first study in itself to document cellular morphologic details in patients of pemphigus vulgaris (PV) by scanning electron microscopy (SEM) in Indian population. This study was carried out with the aim of studying the cellular morphology and changes in the cell structures in patients of PV by SEM. Materials and Methods: The study consisted of four smears each from six patients belonging to the age group of 20-45 years comprising of two males and four females diagnosed for PV. The slides were then viewed under SEM. Results: The pathologic cell showed uneven cell boundaries with irregular arrangement of ridges forming a complex pattern; also the irregular elevations of plasma membrane formed a "plaque" like appearance on the cell boundaries. Conclusion: This study has added new observations related to the cellular changes and morphology seen in patients of PV, and numerous hypotheses are also stated to correlate with the possible etiopathogenesis of PV. In future, these observations may be useful in learning the pathogenesis of the disease even in the absence of frank lesions of the disease.


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